A massage therapist is unable to do her job when stricken with a mysterious and sudden aversion to bodily contact. Meanwhile, her uptight brother's floundering dental practice receives new life when clients seek out his healing touch.

Mourning the death of his brother, Jack's friend Iris invites him to her father's cottage for some alone time to recuperate. Unbeknownst to either of them, Iris's sister Hannah is also staying at their father's cottage recovering from her recent break-up. One entire bottle of tequila later, Jack and Hannah wake up to find Iris at the door. They each have secrets that they're tying to keep and they each have feelings that they're trying to sort out.

Southern Californian Bree Osbourne, who was formerly Stanley Chupak, has finally received the news for which she has been waiting: she has been approved for male-to-female sexual reassignment surgery. But before Margaret, her therapist, will allow her to go through with the surgery scheduled in a week's time, Bree has to deal with an unresolved issue from her past. Bree got a telephone call from a seventeen year old man named Toby Wilkins, who was looking for Stanley, his biological father. Toby is in a New York jail, he who supports himself by petty crime and hustling. Stanley/Bree knew nothing about Toby before the telephone call. Toby apparently is all alone in the world, with his mother having committed suicide and being estranged from his stepfather in Tennessee. Masquerading as a Christian social worker, Bree, not telling him either of her true identity or her transgendered status...

Two down on their luck childhood friends struggle to figure out their lives. Ray a drummer in a rock and roll band, and Owen an aspiring film maker spend most of their time working menial jobs and drinking. When Owen's fiancé Lynn breaks off their engagement he finds himself spiraling, and allows Ray to come along with him to a two bit film festival he has been invited to in Kansas. There Owen makes several attempts to patch up his relationship, while Ray scams them into a deluxe suite at the local Four Seasons hotel by posing as Wally Shawn's son (who happens to be receiving a lifetime achievement award) and generally causes a major ruckus. By the end, Owen decides to make some changes in their relationship and in his life.